Influence of central sidechain on self-assembly of glycine-x-glycine peptides
Lavénia Thursch, Thamires A. Lima, Nichole O’Neill, Fábio Furlan Ferreira, Reinhard Schweitzer‐Stenner, Nicolas J. Alvarez
Abstract
π-π stacking, hydrogen bonding, and hydrophobicity, on the formation of fibrils. We conclude that fibril formation requires π-π stacking interactions in pure water, while hydrogen bonding can form fibrils in the presence of ethanol-water solutions. These results validate and support theoretical arguments on the propensity for self-assembly and leads to a better understanding of the relationship between peptide chemistry and fibril self-assembly. Overall, GxG peptides constitute a unique family of peptides, whose characterization will aid in advancing our understanding of self-assembly driving forces for fibril formation in peptide systems.