Supramolecular localization in liquid–liquid phase separation and protein recruitment in confined droplets
Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto
Abstract
This study investigated the localization of artificial peptide supramolecular fibers in liquid-liquid phase separation (LLPS). Hierarchical organization led to the localization of supramolecules in LLPS droplets. Moreover, proteins were recruited into confined droplets by the physical adsorption of proteins on the supramolecules, enabling an enhanced cascade reaction.
Topics & Concepts
Supramolecular chemistryPhase (matter)Liquid liquidBiophysicsChemistryLiquid phasePeptideNanotechnologyMaterials scienceChemical engineeringCrystallographyChromatographyOrganic chemistryBiochemistryBiologyPhysicsCrystal structureThermodynamicsEngineeringRNA Research and SplicingLipid metabolism and biosynthesisProtein Structure and Dynamics