IRON MAN interacts with BRUTUS to maintain iron homeostasis in <i>Arabidopsis</i>
Yang Li, Chengkai Lu, Chen Yang Li, Rihua Lei, Meng Pu, Jun Zhao, Feng Peng, Hua Qian Ping, Dan Wang, Gang Liang
Abstract
Significance bHLH105 and bHLH115, key transcription factors that positively regulate Fe homeostasis, are both ubiquitinated and degraded by BRUTUS (BTS). How plants activate bHLH105 and bHLH115 under Fe-deficient conditions remains unclear. IRON MAN peptides (IMAs) are a class of small peptides that are induced by Fe deficiency and are required for Fe homeostasis, but how they regulate Fe homeostasis is also not known. Here, we established that IMA peptides sequester BTS and promote the accumulation of bHLH105 and bHLH115, thereby activating the Fe deficiency response in Arabidopsis .
Topics & Concepts
ArabidopsisIron homeostasisHomeostasisChemistryCell biologyBiologyBiochemistryGeneMutantPlant Micronutrient Interactions and EffectsPlant Stress Responses and TolerancePlant nutrient uptake and metabolism