Strong Dependence between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma
Anna Birková, Marcela Valko-Rokytovská, Beáta Hubková, Marianna Zábavníková, Mária Mareková
Abstract
Urine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a significant negative correlation between autofluorescence and Clark classification. Based on our results, it is assumed that the way malignant melanoma grows also affects urinary autofluorescence.
Topics & Concepts
AutofluorescenceMelanomaUrineUrinary systemFluorescenceTryptophanChemistryStage (stratigraphy)MedicinePathologyInternal medicineCancer researchBiologyOpticsBiochemistryPaleontologyAmino acidPhysicsSkin Protection and Agingmelanin and skin pigmentationPhotodynamic Therapy Research Studies