pIChemiSt ─ Free Tool for the Calculation of Isoelectric Points of Modified Peptides
Andrey I. Frolov, Sunay V. Chankeshwara, Zeyed Abdulkarim, Gian Marco Ghiandoni
Abstract
prediction tools, ACDlabs and pKaMatcher, correspondingly. The method is available in the form of an open source Python library at https://github.com/AstraZeneca/peptide-tools, which can be integrated into other proprietary and free software packages. We anticipate that the pI calculation tool may facilitate optimization and purification activities across various application domains of peptides, including the development of biopharmaceuticals.
Topics & Concepts
Isoelectric pointPeptideCombinatorial chemistryComputer scienceSequence (biology)Isoelectric focusingChemistryComputational biologyBiochemistryBiologyEnzymeChemical Synthesis and AnalysisComputational Drug Discovery MethodsClick Chemistry and Applications