Full Copper Resistance in Cupriavidus metallidurans Requires the Interplay of Many Resistance Systems
Niklas Hirth, Michelle‐Sophie Gerlach, Nicole Wiesemann, Martin Herzberg, Cornelia Große, Dietrich H. Nies
Abstract
The ability of bacteria to maintain homeostasis of the essential-but-toxic “Janus”-faced element copper is important for their survival in many natural environments but also in case of pathogenic bacteria in their respective host. The most important contributors to copper homeostasis have been identified in the last decades and comprise P IB1 -type ATPases, periplasmic copper- and oxygen-dependent copper oxidases, transenvelope efflux systems, and glutathione; however, it is not known how all these players interact.
Topics & Concepts
CopperMicrobiologyBiologyChemistryOrganic chemistryExtraction and Separation ProcessesChromium effects and bioremediationEnvironmental remediation with nanomaterials