Prognostic Implications of Comprehensive Whole Vessel Plaque Quantification Using Coronary Computed Tomography Angiography
Seokhun Yang, Joo Myung Lee, Masahiro Hoshino, Tadashi Murai, Ki Hong Choi, Doyeon Hwang, Kyung-Jin Kim, Eun‐Seok Shin, Joon‐Hyung Doh, Hyuk‐Jae Chang, Chang‐Wook Nam, Jinlong Zhang, Jianan Wang, Shao‐Liang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Akasaka, Tsunekazu Kakuta, Bon‐Kwon Koo
Abstract
Background: The prognostic value of whole vessel plaque quantification has not been fully understood. Objectives: We aimed to investigate the clinical relevance of whole vessel plaque quantification on coronary computed tomography angiography. Methods: , or percent total atheroma volume ≥32.2% in a target vessel, based on corresponding optimal cutoff values. Survival analysis for vessel-oriented composite outcome (VOCO) (a composite of cardiac death, target vessel myocardial infarction, or target vessel revascularization) at 5 years was performed using marginal Cox proportional hazard models. Results: 0.001). In a landmark analysis at 2 years, the number of HRVC showed sustained prognostic implications beyond 2 years, but the number of HRPC did not. Conclusions: Whole vessel plaque quantification can provide incremental predictability for low FFR and additive prognostic value in deferred vessels with high FFR over anatomical severity and lesion plaque characteristics. (CCTA-FFR Registry for Risk Prediction; NCT04037163).