Bicyclic (alkyl)(amino)carbene (BICAAC) as a metal-free catalyst for reduction of nitriles to amines
Nimisha Gautam, Ratan Logdi, P Sreejyothi, Natesan Mannangatti Rajendran, Ashwani Kumar Tiwari, Swadhin K. Mandal
Abstract
Bicyclic (alkyl)(amino)carbene (BICAAC) is introduced as a metal-free catalyst for the reduction of various nitriles to the corresponding amine hydrochloride salts in the presence of pinacolborane. Mechanistic investigations combining experiments and DFT calculations suggest a B-H addition to the carbene center, which acts as a carrier of the hydride source.
Topics & Concepts
CarbeneBicyclic moleculeAlkylChemistryCatalysisAmine gas treatingMedicinal chemistryHydrideHydrochlorideMetalOrganic chemistryCombinatorial chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis