Diabetes and cognitive decline: Challenges and future direction
Norhamidar Ab-Hamid, Norsuhana Omar, Che Aishah Nazariah Ismail, Idris Long
Abstract
There is growing evidence that diabetes can induce cognitive decline and dementia. It is a slow, progressive cognitive decline that can occur in any age group, but is seen more frequently in older individuals. Symptoms related to cognitive decline are worsened by chronic metabolic syndrome. Animal models are frequently utilized to elucidate the mechanisms of cognitive decline in diabetes and to assess potential drugs for therapy and prevention. This review addresses the common factors and pathophysiology involved in diabetes-related cognitive decline and outlines the various animal models used to study this condition.
Topics & Concepts
Cognitive declineMedicineDementiaDiabetes mellitusCognitionGerontologyDiseasePsychiatryPathologyEndocrinologyAdvanced Glycation End Products researchNeurological Disease Mechanisms and TreatmentsNeurological Disorders and Treatments