Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice
Levi Todd, Connor Finkbeiner, Claire K. Wong, Marcus Hooper, Thomas A. Reh
Abstract
The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that in mice, microglia inhibit the Ascl1-mediated retinal regeneration, suggesting that the innate immune system limits the regenerative response to injury.
Topics & Concepts
NeurogenesisMuller gliaMicrogliaRegeneration (biology)Retinal regenerationInnate immune systemBiologyCell biologyRetinalRetinaTranscription factorNeuroscienceImmune systemInflammationImmunologyStem cellProgenitor cellGeneticsBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsRetinal Development and DisordersNeurogenesis and neuroplasticity mechanisms