<i>In Vitro</i> Activity and <i>In Vivo</i> Efficacy of Cefiderocol against Stenotrophomonas maltophilia
Rio Nakamura, Merime Oota, Shuhei Matsumoto, Takafumi Sato, Yoshinori Yamano
Abstract
Cefiderocol is a novel siderophore cephalosporin antibiotic with broad coverage against difficult-to-treat Gram-negative bacteria, including those resistant to carbapenems. Its activity against Stenotrophomonas maltophilia was investigated in vitro against clinical isolates and in lung infection models using strains either resistant (SR202006) or susceptible (SR201934, SR200614) to trimethoprim-sulfamethoxazole.
Topics & Concepts
Stenotrophomonas maltophiliaStenotrophomonasIn vivoGram-negative bacterial infectionsIn vitroBiologyMicrobiologyPseudomonas aeruginosaBacteriaPseudomonasAntibioticsBiotechnologyBiochemistryGeneticsInfections and bacterial resistanceBacterial biofilms and quorum sensing