Biomaterials-based immunomodulation enhances survival of murine vascularized composite allografts
Sven D. Sommerfeld, Xianyu Zhou, Joscelyn C. Mejías, Byoung Chol Oh, David R. Maestas, Georg J. Furtmüller, Philippe Laffont, Jennifer H. Elisseeff, Gerald Brandacher
Abstract
= 0.0067; Mantel-Cox test). These studies implicate the clinical exploration of combined regimens involving local application of pro-regenerative, immunomodulatory biomaterials in surgical wound sites with targeted co-stimulatory blockade to reduce adverse effects of immunosuppression and enhance graft survival in VCA.
Topics & Concepts
ImmunosuppressionImmune systemExtracellular matrixImmunologyAllotransplantationTransplantationCancer researchMedicineImmune toleranceBiologyCell biologyInternal medicineOrgan and Tissue Transplantation ResearchTissue Engineering and Regenerative MedicineReconstructive Surgery and Microvascular Techniques