Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells in vitro and in vivo
Liang Shi, Zhenyong Wang, Xiuchao Geng, Yuhao Zhang, Ziqing Xue
Abstract
. Furthermore, 16 genes were identified as potential downstream targeting genes of miRNA-34. Taken together, GCFs-derived exosomal miRNA-34 may be a promising targeting molecule for therapeutic strategies in GC.
Topics & Concepts
MicrovesiclesCarcinogenesismicroRNACancer researchBiologyCancer cellIn vivoTumor microenvironmentCancer-Associated FibroblastsCancerTumor progressionCell growthCell cultureCell biologyGeneGeneticsTumor cellsExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases