Pharmacological and genetic inhibition of ARG2 in CXCR2<sup>Hi</sup> myeloid-derived suppressor cells combats sepsis-induced lymphopenia
Qiuyue Long, Shixu Song, Jiwei Li, Jialing Gan, Shuoqi Yang, Boyu Li, Hongli Ye, Binghan Zheng, Fangfang Wu, Zhichen Yu, Jing Wu, Linyu Ding, Mingzheng Jiang, Xiaoyi Hu, Zhancheng Gao, Yali Zheng
Abstract
MDSC-derived ARG2 as a promising target of immune enhancement therapy in sepsis.
Topics & Concepts
SuppressorSepsisMyeloid-derived Suppressor CellImmunologyMyeloidCXC chemokine receptorsCancer researchBiologyMedicinePharmacologyChemistryInflammationGeneticsChemokineGeneChemokine receptorInflammation biomarkers and pathwaysSepsis Diagnosis and TreatmentAmoebic Infections and Treatments