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AIMNet2: a neural network potential to meet your neutral, charged, organic, and elemental-organic needs

Dylan M. Anstine, R.I. Zubatyuk, Olexandr Isayev

2025Chemical Science99 citationsDOIOpen Access PDF

Abstract

hybrid DFT level of theory quantum chemical calculations, AIMNet2 combines ML-parameterized short-range and physics-based long-range terms to attain generalizability that reaches from simple organics to diverse molecules with "exotic" element-organic bonding. We show that AIMNet2 outperforms semi-empirical GFN2-xTB and is on par with reference density functional theory for interaction energy contributions, conformer search tasks, torsion rotation profiles, and molecular-to-macromolecular geometry optimization. Overall, the demonstrated chemical coverage and computational efficiency of AIMNet2 is a significant step toward providing access to MLIPs that avoid the crucial limitation of curating additional quantum chemical data and retraining with each new application.

Topics & Concepts

Generalizability theoryParameterized complexityDensity functional theoryComputer scienceArtificial neural networkOrganic moleculesMoleculeQuantum chemistryValence (chemistry)QuantumRange (aeronautics)Quantum chemicalComputational chemistryChemistryBiological systemStatistical physicsArtificial intelligenceMachine learningAlgorithmMaterials sciencePhysicsQuantum mechanicsMathematicsSupramolecular chemistryBiologyComposite materialStatisticsMachine Learning in Materials ScienceComputational Drug Discovery MethodsProtein Structure and Dynamics
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