Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline
Janos Groh, Konrad Knöpper, Panagiota Arampatzi, Xidi Yuan, Lena Lößlein, Antoine‐Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini
Topics & Concepts
Cytotoxic T cellAxonNeuroscienceBiologyCentral nervous systemImmune systemNeuroinflammationCognitive declineMyelinCD8MicrogliaImmunosenescenceInflammationImmunologyMedicinePathologyDiseaseBiochemistryDementiaIn vitroNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerNeurogenesis and neuroplasticity mechanisms