Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory
Azam Asgarihafshejani, Ève Honoré, François-Xavier Michon, Isabel Laplante, Jean‐Claude Lacaille
Abstract
regulates learning-induced LTP at PC-SOM synapses, as well as contextual fear memory. Thus, LTP of PC-SOM synapses is a long-term feedback mechanism controlling pyramidal cell synaptic plasticity, sufficient to regulate memory consolidation.
Topics & Concepts
Long-term potentiationNeuroscienceMetaplasticityOptogeneticsMemory consolidationExcitatory postsynaptic potentialNeuronal memory allocationSynaptic plasticityPyramidal cellHippocampal formationSchaffer collateralSynapseLTP inductionBiologyHippocampusSynaptic augmentationInhibitory postsynaptic potentialReceptorBiochemistryNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics researchMemory and Neural Mechanisms