Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges
Shenxin Zeng, Wenhai Huang, Xiaoliang Zheng, Liyan Cheng, Zhimin Zhang, Jian Wang, Zhengrong Shen
Topics & Concepts
Drug discoveryUbiquitin ligaseComputational biologyProtein degradationChemistryAndrogen receptorUbiquitinProteasomeProteolysisDrug developmentDrugProstate cancerBioinformaticsPharmacologyMedicineCancerBiologyBiochemistryEnzymeInternal medicineGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways