An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery
Bo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi Liu, Pei‐Shan Chung, Harold G. Monbouquette, Pei‐Yu Chiou, Nigel T. Maidment
Abstract
A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.
Topics & Concepts
AnalyteMicroprobeMaterials scienceNanotechnologyBiomedical engineeringChemistryChromatographyEngineeringMineralogyNeuroscience and Neural EngineeringAnalytical Chemistry and SensorsForce Microscopy Techniques and Applications