Pericytes and shear stress each alter the shape of a self-assembled vascular network
Kazuya Fujimoto, Scott Erickson, Masamune Nakayama, Hiroki Ihara, Kei Sugihara, Yuji Nashimoto, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa
Abstract
). Experimental results show that pericytes limit vascular diameter. Interestingly, when treated with imatinib or crenolanib, which are chemotherapeutic drugs and inhibitors of platelet-derived growth factor receptor β (PDGFRβ), the pericyte coverage of vessels decreased significantly but vessel diameter remained unchanged. This furthers our understanding of the mechanisms underlying vascular development and demonstrates the value of this microfluidic device in future studies on drug development and vascular biology.
Topics & Concepts
Shear stressAngiogenesisPericyteOrgan-on-a-chipBlood vesselCell biologyMicrofluidicsNanotechnologyMaterials scienceBiologyChemistryCancer researchEndothelial stem cellComposite materialEndocrinologyBiochemistryIn vitroAngiogenesis and VEGF in Cancer3D Printing in Biomedical ResearchMathematical Biology Tumor Growth