An isogenic cell line panel for sequence-based screening of targeted anticancer drugs
Ashley L. Cook, Nicolas Wyhs, Surojit Sur, Blair Ptak, Maria Popoli, Laura Dobbyn, Tasos Papadopoulos, Chetan Bettegowda, Nickolas Papadopoulos, Bert Vogelstein, Shibin Zhou, Kenneth W. Kinzler
Abstract
. These cell lines and screening approach should prove useful for researchers studying a variety of cellular and biochemical phenomena.
Topics & Concepts
Cell cultureComputational biologyCRISPRGeneBiologyHigh-throughput screeningGeneticsGenomicsDrug discoveryCancer cell linesCancerCancer researchCancer cellBioinformaticsGenomeCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomicsVirus-based gene therapy research