Prospective Cohort Study of Population Pharmacokinetics and Pharmacodynamic Target Attainment of Vancomycin in Adults on Extracorporeal Membrane Oxygenation
Younghee Jung, Dong Hwan Lee, Hyoung Soo Kim
Abstract
) when the MIC was presumed to be 1 mg/liter. However, AUC/MIC values of 400 to 600 were difficult to attain with any dosing strategy regardless of MIC and eGFR. Thus, it is hard to achieve efficacy and safety targets in patients on ECMO using the population dosing approach with Monte Carlo simulations, and therapeutic drug monitoring should be implemented in these patients.
Topics & Concepts
PharmacokineticsPharmacodynamicsMedicineVancomycinExtracorporeal membrane oxygenationProspective cohort studyPopulationPharmacologyPopulation pharmacokineticsAnesthesiaInternal medicineBiologyBacteriaEnvironmental healthGeneticsStaphylococcus aureusAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in StaphylococcusMechanical Circulatory Support Devices