SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
Di Wang, Yun‐Kai Lin, Feihong Xu, Hui Zhang, Xiaoyan Zhu, Zhen Liu, Yuan Hu, Guanjun Dong, Bingqi Sun, Yanhong Yu, Guoren Ma, Zhigang Tang, Diana Legarda, Adrian T. Ting, Yuan Liu, Jia Hou, Liwei Dong, Huabao Xiong
Abstract
BACKGROUND: To determine whether SIRPα can be a diagnostic marker of pulmonary tuberculosis (PTB) and the molecular mechanism of SIRPα regulating macrophages to kill Mycobacterium tuberculosis (MTB). METHODS: and wide type macrophages transplanted C57BL/6J mice were used to determine the function of SIRPα on MTB infection in vivo. FINDINGS: →WT treatment could decrease the inflammation and maintain the bactericidal capacity. INTERPRETATION: Our data define SIRPα a novel biomarker for tuberculosis infection and underlying mechanisms for maintaining macrophage homeostasis. FUNDING: This work was financially supported by the Chinese National Natural Science Foundation project (No.81401635). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.