Type IV Pilus-Mediated Inhibition of <i>Acinetobacter baumannii</i> Biofilm Formation by Phenothiazine Compounds
Nam Xuan Vo, Benjamin S. Sidner, Yafan Yu, Kurt H. Piepenbrink
Abstract
Acinetobacter infections are a growing burden on health care systems worldwide due to increasing antimicrobial resistance through multiple mechanisms. Biofilm formation is an established mechanism of antimicrobial resistance, and its inhibition has the potential to potentiate the use of existing drugs against pathogenic Acinetobacter. Additionally, as discussed in the manuscript, anti-biofilm activity by phenothiazines has the potential to help to explain their known activity against other bacteria, including Staphylococcus aureus and Mycobacterium tuberculosis.
Topics & Concepts
BiofilmAcinetobacter baumanniiPilusMicrobiologyPhenothiazineChemistryAcinetobacterBiologyBacteriaPharmacologyBiochemistryGeneticsAntibioticsEscherichia coliGenePseudomonas aeruginosaPhenothiazines and Benzothiazines Synthesis and ActivitiesAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing