Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis
Chenxi Cao, Fei Wu, Xingyue Niu, Xiaoqing Hu, Jin Cheng, Yan Zhang, Chuanyun Li, Xiaoning Duan, Xin Fu, Jiying Zhang, Xin Zhang, Yingfang Ao
Abstract
Cadherin-11 plays an important role in the pathogenesis of PVNS and forms a positive feedback loop with inflammatory factors, which further activates the NF-κB and MAPK pathways to trigger an inflammatory cascade. Cadherin-11-mediated inflammation results in PVNS with high recurrence, invasiveness, and strong cartilage destruction ability, and eventually promotes the transformation of PVNS from the initial inflammatory disease to neoplastic disease. Thus, inhibition of cadherin-11 together with its related inflammatory reaction, represents a new therapeutic strategy for PVNS.
Topics & Concepts
Pigmented villonodular synovitisCadherinFibroblastSynovitisInflammationCell biologyCancer researchChemistryPathologyMedicineBiologyImmunologyIn vitroCellRheumatoid arthritisBiochemistryMusculoskeletal synovial abnormalities and treatments