Rational development of molecularly imprinted nanoparticles for blocking PD-1/PD-L1 axis
Zikuan Gu, Shuxin Xu, Zhanchen Guo, Zhen Liu
Abstract
steric hindrance, this inhibitor could effectively block PD-1/PD-L1 interaction. Besides, it could effectively reactivate T cells and reverse the chemoresistance of tumor cells. Therefore, this present study not only provides a novel and promising immune checkpoint blockade inhibitor but also boosts further development of MIPs for cancer immunotherapy.
Topics & Concepts
Monoclonal antibodyEpitopeBlocking (statistics)Molecularly imprinted polymerImmunotherapyPD-L1Cancer immunotherapyChemistryImmune systemBlocking antibodyAntibodyImmune checkpointCancer researchCombinatorial chemistryMedicineBiochemistryImmunologyCatalysisComputer scienceSelectivityComputer networkCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionInhalation and Respiratory Drug Delivery