Mt-Keima detects PINK1-PRKN mitophagy <i>in vivo</i> with greater sensitivity than mito-QC
Yiting Liu, Danielle A. Sliter, Mario K. Shammas, Xiaoping Huang, Chunxin Wang, Hannah Calvelli, Dragan Maric, Derek P. Narendra
Abstract
DFP: deferiprone; EE: exhaustive exercise; FBS: fetal bovine serum; OAQ: oligomycin, antimycin, and Q-VD-OPH; OMM: outer mitochondrial membrane; PBS: phosphate-buffered saline; PD: Parkinson disease; UPS: ubiquitin-proteasome system.
Topics & Concepts
MitophagyPINK1BiologyIn vivoAutophagyMitochondrionCell biologyApoptosisBiochemistryGeneticsAutophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments