Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection
Xiao-Shuang Zheng, Qi Wang, Juan Min, Xu-Rui Shen, Qian Li, Qiuchen Zhao, Xi Wang, Ren-Di Jiang, Rong Geng, Ying Chen, Yan Zhu, Bei Li, Wei Zhang, Ang Li, Tingting Xie, Meiqin Liu, Liang Cheng, Zheng‐Li Shi, Peng Zhou
Abstract
We demonstrated the single-cell landscape in lung and spleen upon SARS-CoV-2 infection in an acute severe disease mouse model that replicated human symptoms, including severe lung pathology and lymphopenia. Our comprehensive study revealed the key role of neutrophil-mediated lung immunopathology in SARS-CoV-2-induced severe pneumonia, which not only helped our understanding of COVID-19 but also warranted the concept of neutrophil targeting therapeutics in COVID-19 treatment.
Topics & Concepts
BiologyImmunopathologyImmunologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyBetacoronavirus2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)NeutrophileInflammationInfectious disease (medical specialty)PathologyDiseaseOutbreakMedicineCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Immune responses and vaccinations