Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil
Aluísio J. D. Barros, César G. Victora, Ana Maria Baptista Menezes, Bernardo Lessa Horta, Fernando C. Barros, Fernando Pires Hartwig, Gabriel D. Victora, Luís Paulo Vidaletti, Mariângela Freitas da Silveira, Marília Arndt Mesenburg, Nadège Jacques, Cláudio J. Struchiner, Flávia Roberta Brust, Marinel Mór Dall’Agnol, Ana Paula Longaray Delamare, Carlos Henrique Ramires François, Maria Letícia Rodrigues Ikeda, Débora da Cruz Payão Pellegrini, Cézane Priscila Reuter, Shana Ginar da Silva, Odir Antônio Dellagostin, Pedro Curi Hallal
Abstract
OBJECTIVE: To describe the evolution of seropositivity in the State of Rio Grande do Sul, Brazil, through 10 consecutive surveys conducted between April 2020 and April 2021. METHODS: Nine cities covering all regions of the State were studied, 500 households in each city. One resident in each household was randomly selected for testing. In survey rounds 1-8 we used the rapid WONDFO SARS-CoV-2 Antibody Test (Wondfo Biotech Co., Guangzhou, China). In rounds 9-10, we used a direct ELISA test that identifies IgG to the viral S protein (S-UFRJ). In terms of social distancing, individuals were asked three questions, from which we generated an exposure score using principal components analysis. RESULTS: Antibody prevalence in early April 2020 was 0.07%, increasing to 10.0% in February 2021, and to 18.2% in April 2021. In round 10, self-reported whites showed the lowest seroprevalence (17.3%), while indigenous individuals presented the highest (44.4%). Seropositivity increased by 40% when comparing the most with the least exposed. CONCLUSIONS: The proportion of the population already infected by SARS-Cov-2 in the state is still far from any perspective of herd immunity and the infection affects population groups in very different levels.