Oncofetal TRIM71 drives liver cancer carcinogenesis through remodeling CEBPA-mediated serine/glycine metabolism
Ying Su, Ziteng Li, Qin Li, Xinyi Guo, Hena Zhang, Zhiyong Li, Zhiqiang Meng, Shenglin Huang, Zhixiang Hu
Abstract
We demonstrated the oncofetal status in liver cancer and highlighted the crucial role of TRIM71 and provided potential therapeutic strategies and liver cancer-specific biomarker for liver cancer patients.
Topics & Concepts
CarcinogenesisSerineCancer researchGlycineCancerCEBPALiver cancerChemistryBiologyCell biologyMedicineInternal medicineTranscription factorBiochemistryPhosphorylationHepatocellular carcinomaAmino acidGeneRNA modifications and cancerinterferon and immune responsesBiochemical and Molecular Research