Antibacterial silver and gold complexes of imidazole and 1,2,4-triazole derived N-heterocyclic carbenes
Joel C. Mather, Jessica A. Wyllie, A. Hamilton, Tatiana P. Soares da Costa, Peter J. Barnard
Abstract
A series of gold( i ) and silver( i ) complexes of 1,2,4-triazolylidene and imidazolylidene based N-heterocyclic carbene ligands were prepared that show excellent antibacterial activity against clinically relevant bacterial pathogens.
Topics & Concepts
ImidazoleCarbeneChemistryTriazoleCombinatorial chemistryAntibacterial activityAntimicrobial1,2,4-TriazoleStereochemistryMedicinal chemistryOrganic chemistryBacteriaBiologyCatalysisGeneticsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsClick Chemistry and Applications