Cooperative Self-Assembled Nanoparticle Induces Sequential Immunogenic Cell Death and Toll-Like Receptor Activation for Synergistic Chemo-immunotherapy
Yaoqi Wang, Zenghui Wang, Binlong Chen, Qingqing Yin, Meijie Pan, Heming Xia, Bo Zhang, Yue Yan, Zhujun Jiang, Qiang Zhang, Yiguang Wang
Abstract
T cells in tumors and provoke a strong antitumor immune response toward primary and abscopal tumors in B16-OVA and CT26 tumor-bearing mice models. The cooperative self-assembled nanoparticle strategy provides a potential candidate of nanomedicine to advance the synergistic cancer chemo-immunotherapy.
Topics & Concepts
Tumor microenvironmentImmunogenic cell deathImmunotherapyCancer researchCancer immunotherapyImmunogenicityImmune systemEndosomeChemistryLymphMedicineImmunologyReceptorPathologyBiochemistryNanoplatforms for cancer theranosticsCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses