Hypoxia imaging in living cells, tissues and zebrafish with a nitroreductase-specific fluorescent probe
Li Fan, Qi Zan, Bo Lin, Xiaodong Wang, Xiaojuan Gong, Zhonghua Zhao, Shaomin Shuang, Chuan Dong, Man Shing Wong
Abstract
. Most notably, NTNO has been successfully used for imaging hypoxia levels in living cells, tumor tissues and zebrafish, making it of great potential to monitor NTR in biological systems.
Topics & Concepts
NitroreductaseZebrafishFluorescenceHypoxia (environmental)ChemistryFluorescence-lifetime imaging microscopyCell biologyBiophysicsBiochemistryBiologyOxygenEnzymeGeneOrganic chemistryPhysicsQuantum mechanicsCancer, Hypoxia, and MetabolismNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniques