Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy
Vibha Singh, Siddhant Bhoir, Rupesh V. Chikhale, Javeena Hussain, Donard S. Dwyer, Richard A. Bryce, Sivapriya Kirubakaran, Arrigo De Benedetti
Abstract
and in LNCaP xenografts, which has potential for clinical investigation in combination with ADT. J54 has low affinity for the dopamine receptor in modeling and competition studies and weak detrimental behavioral effects in mice and
Topics & Concepts
LNCaPProstate cancerPhenothiazineApoptosisPharmacologyAndrogen deprivation therapyCancer researchAndrogen receptorIn vitroChemistryCancerMedicineInternal medicineBiochemistryPhenothiazines and Benzothiazines Synthesis and ActivitiesReceptor Mechanisms and SignalingCancer therapeutics and mechanisms