Ovarian Cancer: Multi-Omics Data Integration
Anna A. Kliuchnikova, Arina I. Gordeeva, Aziz Abdurakhimov, Tatiana A. Materova, Svetlana Tarbeeva, Elizaveta Sarygina, Anna Kozlova, Olga I. Kiseleva, Elena A. Ponomarenko, Ekaterina V. Ilgisonis
Abstract
This study focuses on the systematization and integration of ovarian cancer multi-omics data, revealing patterns in the application of different omics-based approaches and assessing factors that affect the identification of potential biomarkers. An integrative analysis of 51 publications revealed 1649 potential biomarkers. The findings emphasized the molecular diversity of ovarian cancer. They demonstrated the importance of performing the comprehensive integration of molecular and clinical data to search for diagnostic alternatives and molecular patterns underlying ovarian cancer. The heterogeneity of data sources, differences in data acquisition and analysis protocols, and the lack of uniform standards affect the reproducibility of the results of genomic and post-genomic profiling. Multi-omics studies are more promising than mono-omics-based ones. Despite technological advances, researchers continue to focus on results obtained over a decade ago, which may hinder the scientific community from exploring new horizons in ovarian cancer research.