Association between ABO Blood Groups and Type 2 Diabetes Mellitus:A Meta-Analysis
Earl Adriane Cano, Marion Agatha Esguerra, Ariane Michaela Batausa, Jessica Rose Baluyut, Ria Cadiz, Hewmy Franci Docto, Jose Ramir Encabo, Reena Mae Gomez, Maria Gina Sadang
Abstract
BACKGROUND: The role of the ABO blood group goes beyond immunohematology as there is accumulating evidence on its association with type 2 diabetes mellitus. However, findings regarding the relation have been contradictory and there is a need to determine the validity of claims. OBJECTIVE: Evaluate the susceptibility of the ABO blood groups to type 2 diabetes mellitus. METHOD: index. Random-effects model was used to measure the risk ratio and confidence intervals. Evaluation of publication bias was done using the funnel plot method; further supported by Egger's linear regression test and Begg's test. RESULTS: The relative susceptibility of ABO blood groups to type 2 diabetes mellitus differs for blood type A (Relative risk [RR] = 1.05, 95% CI, 0.93 to 1.18), blood type B (RR = 1.03, 95% CI, 0.91 to 1.18), blood type AB (RR = 1.25, 95% CI, 0.78 to 1.99), and blood type O (RR = 1.11, 95% CI, 0.82 to 1.48). The highest risk of acquiring the disease was seen in type AB individuals, while the lowest risk was seen in type B individuals. CONCLUSION: A significant association was found between ABO blood groups and type 2 diabetes mellitus. ABO phenotype can therefore be considered a possible risk factor or potential genetic determinant of the disease, which can be used to improve diagnosis and treatment.