Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation
Esraa Abdo Moustafa, Heba Abdelrasheed Allam, Marwa A. Fouad, Ahmed M. El Kerdawy, Nahed N. E. El-Sayed, Christoph Wagner, Hatem A. Abdel‐Aziz, Manal Abdel Fattah Ezzat
Topics & Concepts
PharmacophoreLipinski's rule of fiveChemistryGSK-3ADMEIn vivoDocking (animal)Lead compoundDrug discoveryIC50In vitroStaurosporineIn silicoStereochemistryPharmacologyEnzymeBiochemistryKinaseProtein kinase ABiologyMedicineBiotechnologyNursingGeneComputational Drug Discovery MethodsCholinesterase and Neurodegenerative DiseasesWnt/β-catenin signaling in development and cancer