Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children
Cynthia A. Moylan, Alisha Mavis, Dereje D. Jima, Rachel L. Maguire, Mustafa R. Bashir, Jeongeun Hyun, Melanie Cabezas, Alice Parish, Donna Niedzwiecki, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, Cathrine Hoyo
Abstract
genes. These two CpG sites were also significantly associated with a NAFLD diagnosis. As higher LFC associates with an adverse cardiometabolic profile already in childhood, altered DNAm may identify these children early in disease course for targeted intervention. Larger, longitudinal studies are needed to validate these findings and determine mechanistic relevance.
Topics & Concepts
dNaMFatty liverDNA methylationBiologyCohortEpigeneticsCpG siteInternal medicineBiomarkerMethylationDifferentially methylated regionsBioinformaticsOncologyEndocrinologyDiseaseMedicineGeneticsGeneGene expressionLiver Disease Diagnosis and TreatmentEpigenetics and DNA MethylationBirth, Development, and Health