Cationic porphyrin-based nanoparticles for photodynamic inactivation and identification of bacteria strains
Lin Li, Yan Wang, Tao Huang, Xiaodong He, Kai Zhang, E. T. Kang, Liqun Xu
Abstract
) under 635 nm laser irradiation. The cationic porphyrin-based NPs displayed intrinsic antibacterial properties, and exhibited strong APDT effect on Gram-positive bacteria by destroying the bacterial cell membranes. Upon incubation with different bacterial strains, it was found that they could be utilized to identify Gram-positive bacteria by observing the sedimentation behavior of their mixtures, and visualizing their co-cultured and centrifugal bacteria cakes. In addition, the cationic porphyrin-based NPs had good hemocompatibility and low dark cytotoxicity.
Topics & Concepts
PorphyrinCationic polymerizationChemistryCombinatorial chemistryEthylene glycolSinglet oxygenPhotosensitizerAntibacterial activityBacterial cell structureBacteriaOrganic chemistryOxygenBiologyGeneticsPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry