Young Onset Parkinson’s Disease: A Modern and Tailored Approach
Bart Post, Lieneke van den Heuvel, Teije van Prooije, Xander van Ruissen, Bart van de Warrenburg, Jorik Nonnekes
Abstract
In people with young onset Parkinson's disease (YOPD), onset of symptoms is between 21 and 40 years of age. The distinction between YOPD and late-onset Parkinson's disease is supported by genetic differences (a genetic etiology is more common in people with YOPD) and clinical differences (e.g., dystonia and levodopa-induced dyskinesias are more common inYOPD). Moreover, people with YOPD tend to have different family and societal engagements compared to those with late-onset PD. These unique features have implications for clinical management, and call for a tailored multidisplinary approach involving shared-decision making.
Topics & Concepts
EtiologyDiseaseAge of onsetDystoniaLevodopaMedicineParkinson's diseasePsychologyPediatricsPsychiatryInternal medicineParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsGenetic Neurodegenerative Diseases