Design, synthesis, pharmacological evaluation, and <i>in silico</i> studies of the activity of novel spiro pyrrolo[3,4-<i>d</i>]pyrimidine derivatives
Abdullah Yahya Abdullah Alzahrani, Wesam S. Shehab, Asmaa H. Amer, Mohamed G. Assy, Samar M. Mouneir, Maged Abdelaziz, Atef M. Abdel Hamid
Abstract
of 14.50. Our findings are promising in the area of medicinal chemistry for further optimization of the newly designed and synthesized compounds regarding the discussed structure-activity relationship study (SAR), in order to obtain a superior antioxidant lead compound in the near future. All chemical structures of the novel synthesized candidates were unequivocally elucidated and confirmed utilizing spectroscopic and elemental investigations.
Topics & Concepts
PyrimidineIn silicoChemistryCombinatorial chemistryStereochemistryBiochemistryGeneSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsMulticomponent Synthesis of Heterocycles