Treatment of necrobiosis lipoidica with combination Janus kinase inhibition and intralesional corticosteroid
William Damsky, Katelyn Singh, Anjela Galan, Brett King
Abstract
Necrobiosis lipoidica (NL) is an idiopathic granulomatous disorder that causes plaques on the lower part of the legs that commonly ulcerate. Histologically, NL shows palisaded granulomatous inflammation horizontally layered within degenerated collagen and an associated lymphoplasmacytic infiltrate. Little is known about the molecular pathogenesis of NL, and no reliably effective therapies exist.
Topics & Concepts
Necrobiosis lipoidicaMedicinePathogenesisPathologyJanus kinaseInflammationGranulomatous inflammationPyoderma gangrenosumDermatologyImmunologyDiabetes mellitusCytokineEndocrinologyDiseaseSkin Diseases and DiabetesInflammatory Myopathies and DermatomyositisDermatological and Skeletal Disorders