Silencing of long non-coding RNA MEG3 alleviates lipopolysaccharide-induced acute lung injury by acting as a molecular sponge of microRNA-7b to modulate NLRP3
Handi Liao, Suning Zhang, Jianou Qiao
Abstract
experiments further confirmed the aforementioned findings. Silencing lncRNA MEG3 augments miR-7b binding to NLRP3 and downregulates NLRP3 expression, which ultimately improves LPS-induced ALI.
Topics & Concepts
Gene silencingmicroRNALipopolysaccharideRNA silencingSpongeLong non-coding RNARNARNA interferenceLungCell biologyBiologyCancer researchChemistryMedicineImmunologyGeneGeneticsInternal medicineBotanyInflammasome and immune disordersCancer-related molecular mechanisms researchNeonatal Respiratory Health Research