APOE Is a Prognostic Biomarker and Correlates with Immune Infiltrates in Papillary Thyroid Carcinoma
Xu Lin, Jing Zhang, Ru-hua Zhao, Wenjing Zhang, Jingfang Wu, Gang Xue
Abstract
Background: Recent research showed that abnormal lipid metabolism was associated with cancers. As one of the genes that can regulate the level of lipid metabolism, abnormal APOE expression was associated with carcinogenesis. However, the clinical value of APOE in papillary thyroid carcinoma (PTC) remains to be determined. Methods: ONCOMINE, GEPIA, UALCAN, STRING, GeneMANIA, LinkedOmics, GSCALite, TISIDB, EPIC and TIMER were utilized to achieve comprehensively bioinformatics analysis of APOE in this study. And the immunohistochemical staining of APOE was used to verify the predicted results.
Topics & Concepts
Immune systemApolipoprotein EBiomarkerCancer researchBiologyMedicineInternal medicineImmunologyDiseaseBiochemistryFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer