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Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance

Chengyan Chu, Anna Jabłońska, Yue Gao, Xiaoyan Lan, Wojciech G. Lesniak, Yajie Liang, Guanshu Liu, Shen Li, Tim Magnus, Monica S. Pearl, Mirosław Janowski, Piotr Walczak

2021Nature Protocols76 citationsDOIOpen Access PDF

Topics & Concepts

MedicineBlood–brain barrierMannitolPharmacologyDrug deliveryBiomedical engineeringAnesthesiaCentral nervous systemNeuroscienceBiologyInternal medicineChemistryBiochemistryOrganic chemistryBarrier Structure and Function StudiesNeurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathology
Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance | Litcius