Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons
Nils Rother, Cansu Yanginlar, Rik G.H. Lindeboom, Siroon Bekkering, Mandy M. T. van Leent, Baranca Buijsers, Inge Jonkman, Mark de Graaf, Marijke Baltissen, Lieke A. Lamers, Niels P. Riksen, Zahi A. Fayad, Willem J. M. Mulder, Luuk B. Hilbrands, Leo A. B. Joosten, Mihai G. Netea, Michiel Vermeulen, Johan van der Vlag, Raphaël Duivenvoorden
Abstract
, which may not be beneficial for the antiviral innate immune response to SARS-CoV-2 infection in patients.
Topics & Concepts
Innate immune systemHydroxychloroquineImmunologyImmune systemInterferonImmunityBiologyInflammationAcquired immune systemMedicineDiseaseInfectious disease (medical specialty)Internal medicineCoronavirus disease 2019 (COVID-19)Immune responses and vaccinationsDiabetes and associated disordersCOVID-19 Clinical Research Studies