Interclass GPCR heteromerization affects localization and trafficking
Rudy Toneatti, Jong M. Shin, Urjita H. Shah, Carl R. Mayer, Justin M. Saunders, Miguel Fribourg, Paul T. Arsenovic, William G.M. Janssen, Stuart C. Sealfon, Juan F. López‐Giménez, Deanna L. Benson, Daniel E. Conway, Javier González‐Maeso
Abstract
R also augmented intracellular localization of mGluR2 in mouse frontal cortex pyramidal neurons. Together, our data suggest that GPCR heteromerization may itself represent a mechanism of receptor trafficking and sorting.
Topics & Concepts
Metabotropic glutamate receptor 2G protein-coupled receptorCell biologyIntracellularBiologyEndosomeMetabotropic glutamate receptorChemistryReceptorBiochemistrySignal transductionGlutamate receptorReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study