Anti-Alzheimer activity of new coumarin-based derivatives targeting acetylcholinesterase inhibition
Nahla N. Kamel, Hanan F. Aly, Ghadha Ibrahim Fouad, Somaia S. Abd El‐Karim, Manal M. Anwar, Yasmin M. Syam, Samia A. Elseginy, Kawkab A. Ahmed, Hoda F. Booles, Mohamed B. Shalaby, Wagdy K. B. Khalil, Rajat Sandhir, Sonam Deshwal, Maha Z. Rizk
Abstract
study investigated the amelioration in the cognitive function of AD-rats treated with 4c through the T-maze and beam balance behavioural tests. Also, 4c detectably ameliorated MDA and GSH, reaching 90.64 and 27.17%, respectively, in comparison to the standard drug (90.64% and 35.03% for MDA and GSH, respectively). The molecular docking study exhibited a good fitting of compound 4c in the active site of the AChE enzyme and a promising safety profile. Compound 4c exhibited a promising anti-Alzheimer's disease efficiency compared to the standard drug donepezil.