NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during <i>Chlamydia</i> Infection
Oanh Pham, Bokyung Lee, Jasmine C. Labuda, A. Marijke Keestra-Gounder, Mariana X. Byndloss, Renée M. Tsolis, Stephen J. McSorley
Abstract
Understanding the initiation of the inflammatory response during Chlamydia infection is of public health importance given the impact of this disease on young women in the United States. Many young women are chronically infected with Chlamydia but are asymptomatic and therefore do not seek treatment, leaving them at risk of long-term reproductive harm due to inflammation in response to infection. Our manuscript explores the role of the endoplasmic reticulum stress response pathway initiated by an innate receptor in the development of this inflammation.
Topics & Concepts
Endoplasmic reticulumChlamydiaInflammationNOD2NOD1ImmunologyInnate immune systemMedicineHarmAsymptomaticChlamydial infectionUnfolded protein responseBiologyPolitical scienceImmune systemInternal medicineCell biologyLawReproductive tract infections researchClostridium difficile and Clostridium perfringens researchPelvic floor disorders treatments