Direct C(sp<sup>3</sup>)–H difluoromethylation <i>via</i> radical–radical cross-coupling by visible-light photoredox catalysis
Wei Xiong, Wen‐Bing Qin, Ya-Shi Zhao, Kai-Zhong Fu, Guo‐Kai Liu
Abstract
The first approach of photoredox catalyzed radical–radical cross-coupling difluoromethylation of C(sp 3 )−H bond was reported, featuring transition metal-free, good functional group tolerance, broad substrate scope and mild reaction conditions.
Topics & Concepts
ChemistryRadicalPhotoredox catalysisPhotochemistryCatalysisScope (computer science)Coupling (piping)Visible spectrumTransition metalCoupling reactionSubstrate (aquarium)PhotocatalysisOrganic chemistryMechanical engineeringComputer scienceProgramming languageGeologyOptoelectronicsPhysicsEngineeringOceanographyFluorine in Organic ChemistryRadical Photochemical Reactions